Dwarfism Research Today is a free monthly online journal that collates and summarizes the latest research about Dwarfism, including details on genetics, diet, mental and motor development.

Endocrine assessment, molecular characterization and treatment of growth hormone insensitivity disorders.

Savage MO, Attie KM, David A, Metherell LA, Clark AJ, Camacho-Hübner C

Paediatric Endocrinology Unit, William Harvey Research Institute, St Bartholomew's Hospital and the London School of Medicine & Dentistry, London, UK. m.o.savage@qmul.ac.uk

Advances in the diagnosis and treatment of growth hormone insensitivity disorders have occurred in the past 15 years. We discuss the current status of endocrine and molecular evaluation, focusing on the pediatric age range. All the identified mutations of the growth hormone receptor are included. Treatment with recombinant human insulin-like growth factor (rhIGF) 1 in classical cases is summarized and new targets for treatment are discussed, together with therapy using the complex formed between rhIGF1 and rhIGF-binding protein 3.

Published 25 August 2006 in Nat Clin Pract Endocrinol Metab, 2(7): 395-407.
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